Can Different Batches Of Biochemical Reagents Be Mixed?

Automatic biochemical analyzer is an instrument used to detect chemical components in human serum. Biochemistry machines are mainly used to test liver function, blood glucose, lipids, kidney function and heart muscle. With the current popularity of fully automatic biochemical analyzers, they are facing more and more problems. In particular, the problem of mixing reagents of different batches is common in the use of fully automated biochemistry analyzers in medical institutions.

In clinical testing, operators often mix reagents of different batches together. Doing so not only saves costs, but is also very convenient. However, no matter which automatic biochemistry analyzer manufacturer and which reagent, because the batch number is not the same automatic biochemistry analyzer reagent, there are the following 3 differences.

1. the time of production is not the same

2. there is a difference in the activity of the instrumental enzymes in the reagents

3. the concentration of substrates that can produce hydrolysis will vary with time.

Therefore, mixing reagents together without calibration may lead to inaccurate test results. In addition, if some automatic biochemistry analyzer reagents are opened for a long time, dust and bacteria will seep into the bottle.

Because some reagents have a large amount of protein and salt, which constitute a more favorable environment for the growth of bacteria. Even if some reagents have preservative components, but the preservative preservative is limited, in fact, most of the manufacturers' reagents on the market do not contain anti-mold agent components inside.

Therefore, in order not to affect the accuracy of clinical test results, it is generally not recommended to mix reagents of different batches.