History and Principles of Hematology Analyzers | Medical Equipment Supplier | Seamaty

release time:2022-09-15 10:40:40

Hematology Analyzer History

The earliest hematology analyzers were based on the principles of capacitance and photoelectric colorimetry. This instrument can only determine red blood cells and white blood cells. And it was susceptible to the interference of many factors.

By 1948, Mr. Coulter adopted the impedance principle to determine the organic fraction of blood, which greatly improved the precision and accuracy of the measurement results. However, the impedance method could only determine the size of the cells.

By the 1980s, the laser method principle was used in hematology analyzers, and the impedance method was combined with the laser method. This method was able to determine not only the size of the cells but also the morphology of the nuclei.

In the mid-1980s, due to the development of high-energy electromagnetic wave technology, the U.S. company Inventor used impedance, laser and high-energy electromagnetic wave technology to simultaneously detect a cell. The cell sorting is then performed through a comprehensive analysis of the data. Because the high-energy electromagnetic wave technology can detect the size and density of the particles inside the cell. There is also the German company Bayer, which uses the principle of combining cytochemical reactions with laser technology to sort and detect leukocytes.

History and Principles of Hematology Analyzers

Principle of the hematology analyzer

Since neutrophils are rich in peroxidase in their cytoplasm, monocytes are second, primitive cells are very rare, and lymphatic and basophils lack this enzyme. Therefore, the blood analyzer can classify neutrophils from lymphatic and basophils using the action of peroxidase. Flow cytometric techniques are also used to count and classify reticulocytes. Some instruments also classify naive cells by using the principle that the amount of lipid content on the membrane of naive and mature cells is different and the amount of sulfated amino acid binding by the cell membrane is different, and the ability to protect the cell membrane is different after the addition of hemolytic agents.

With the development of science and technology, the detection methods of hematology analyzers will certainly become more perfect and accurate.
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